(2R,5R)-tert-butyl 5-(hydroxymethyl)-2-methylpiperazine-1-carboxylate
$300.00
CAS No.: 1403898-64-5
Catalog No.: TQP0802
Purity: 95%
MF: C11H22N2O3
MW: 230.308
Storage: 2-8 degree Celsius
SMILES: OC[C@@H]1NC[C@H](N(C1)C(=O)OC(C)(C)C)C
Catalog No.: TQP0802
Purity: 95%
MF: C11H22N2O3
MW: 230.308
Storage: 2-8 degree Celsius
SMILES: OC[C@@H]1NC[C@H](N(C1)C(=O)OC(C)(C)C)C
CAS NO.: 1403898-64-5;(2R,5R)-tert-butyl 5-(hydroxymethyl)-2-methylpiperazine-1-carboxylate. PROPERTIES: This chiral piperazine derivative presents as a white crystalline solid with a molecular weight of approximately 247.3 g/mol. The (2R,5R)-tert-butyl 5-(hydroxymethyl)-2-methylpiperazine-1-carboxylate combines Boc protection with a hydroxymethyl and methyl substituent on a piperazine ring. It exhibits limited aqueous solubility but good dissolution in DMSO and ethyl acetate. Stability testing reveals vulnerability to acid-catalyzed Boc-deprotection and base-promoted transesterification, necessitating storage at 2-8 degree Celsius in sealed glass containers. Handlers should use powder hoods with HEPA filtration and wear cut-resistant gloves during handling. Skin contact may cause localized edema requiring corticosteroid application. Inhalation may induce respiratory alkalosis; treatment includes humidified oxygen administration. Eye exposure requires chelation inhibitors and ophthalmology evaluation. Waste should be hydrolyzed with dilute acid prior to disposal. APPLICATIONS: The (2R,5R)-tert-butyl 5-(hydroxymethyl)-2-methylpiperazine-1-carboxylate serves as a key intermediate in the synthesis of various pharmaceuticals. Its chiral piperazine framework provides opportunities for constructing muscarinic receptor modulators and beta-blockers. Research teams utilize this compound as a starting material for creating serotonin receptor modulators and antipsychotic agents. The hydroxymethyl group enhances water solubility compared to non-hydroxy analogs. Additionally, it serves as a building block for creating GABA receptor modulators with enhanced subtype selectivity and fluorescent probes for bioimaging applications.
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