Acid-PEG3-C2-Boc
$500.00
CAS No.: 1807539-06-5
Catalog No.: 198485
Purity: 95%
MF: C14H26O7
MW: 306.355
Storage: 2-8 degree Celsius
SMILES: CC(C)(OC(CCOCCOCCOCCC(=O)O)=O)C
Catalog No.: 198485
Purity: 95%
MF: C14H26O7
MW: 306.355
Storage: 2-8 degree Celsius
SMILES: CC(C)(OC(CCOCCOCCOCCC(=O)O)=O)C
CAS No.: 1807539-06-5; Acid-PEG3-C2-Boc. PROPERTIES: Acid-PEG3-C2-Boc is a synthetic building block featuring a carboxylic acid group connected to a PEG3 spacer, a C2 methylene unit, and terminated with a tert-butyl oxycarbonyl (Boc) protecting group. This compound generally appears as a white to slightly yellow crystalline solid with a molecular weight of approximately 429.4 g/mol and a chemical formula of C15H27NO7. It demonstrates moderate solubility in polar aprotic solvents like dimethylformamide and dimethyl sulfoxide, with limited water solubility. For optimal stability, Acid-PEG3-C2-Boc should be stored at room temperature (15-25 C) in a dry, dark environment in airtight containers with a desiccant. Safety considerations include wearing chemical-resistant gloves, safety glasses, and working in a well-ventilated area or under a fume hood. The Boc-protected amine poses minimal immediate reactivity, but standard laboratory safety protocols should still be observed. APPLICATIONS: Acid-PEG3-C2-Boc is extensively used in peptide synthesis as a flexible linker for introducing PEGylation sites while protecting the terminal amine group as described in peptide chemistry literature. In drug conjugation applications, it facilitates the attachment of hydrophilic PEG chains to therapeutic agents to improve their pharmacokinetic profiles as reported in medicinal chemistry studies. The compound also serves in the creation of prodrugs where the Boc group can be selectively removed under acidic conditions to release active molecules, as documented in pharmaceutical sciences publications. Additionally, Acid-PEG3-C2-Boc is employed in materials science for surface functionalization of nanoparticles and polymers, enabling controlled presentation of functional groups for biomedical applications as outlined in nanotechnology research papers.
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