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9-oxa-2-azaspiro[5.5]undecane hydrochloride
$200.00
CAS No.: 1279879-02-5
Catalog No.: LT0013
Purity: 95%
MF: C9H18ClNO
MW: 191.702
Storage: 2-8 degree Celsius
SMILES: Cl.C1NCCCC12CCOCC2
Catalog No.: LT0013
Purity: 95%
MF: C9H18ClNO
MW: 191.702
Storage: 2-8 degree Celsius
SMILES: Cl.C1NCCCC12CCOCC2
CAS NO.: 1279879-02-5;9-oxa-2-azaspiro[5.5]undecane hydrochloride. PROPERTIES: This spirocyclic amine salt appears as a white hygroscopic powder with a molecular weight of approximately 231.3 g/mol (free base). The 9-oxa-2-azaspiro[5.5]undecane hydrochloride combines oxygen and nitrogen heteroatoms in a spirocyclic framework. It exhibits good solubility in water and lower alcohols but limited miscibility in non-polar media. Stability testing reveals tendency to form hydrates above 35% relative humidity, necessitating storage at 2-8 degree Celsius in sealed polyethylene containers. Handlers should employ deliquescence-resistant tools and maintain environmental humidity below 30%. Skin contact may cause chemical burns in presence of moisture. Inhalation may induce bronchial hyperreactivity; treatment includes anticholinergic inhalers. Eye exposure requires extended rinsing and possible corticosteroid application. Waste should be neutralized with sodium bicarbonate prior to disposal. APPLICATIONS: The 9-oxa-2-azaspiro[5.5]undecane hydrochloride serves as a key intermediate in the synthesis of various pharmaceuticals. Its spirocyclic framework provides conformational restriction that enhances receptor binding affinity. Research teams utilize this compound as a starting material for creating GABA receptor modulators and muscarinic receptor antagonists. The spirocyclic amine undergoes reductive amination for constructing tertiary amines with defined stereochemistry. Additionally, it serves as a building block for creating kinase inhibitors with enhanced metabolic stability.
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