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6,9-diazaspiro[4.5]decan-7-one hydrochloride
$400.00
CAS No.: 2197057-51-3
Catalog No.: LT0033
Purity: 95%
MF: C8H15ClN2O
MW: 190.674
Storage: 2-8 degree Celsius
SMILES: Cl.C1CCCC12NC(CNC2)=O
Catalog No.: LT0033
Purity: 95%
MF: C8H15ClN2O
MW: 190.674
Storage: 2-8 degree Celsius
SMILES: Cl.C1CCCC12NC(CNC2)=O
CAS NO.: 2197057-51-3;6,9-diazaspiro[4.5]decan-7-one hydrochloride. PROPERTIES: This spirocyclic amine salt appears as a white hygroscopic powder with a molecular weight of approximately 181.2 g/mol (free base). The 6,9-diazaspiro[4.5]decan-7-one hydrochloride combines two nitrogen atoms in a spirocyclic framework with a ketone functionality. It exhibits good solubility in water and lower alcohols but limited miscibility in non-polar media. Stability testing reveals tendency to form hydrates above 35% relative humidity, necessitating storage at 2-8 degree Celsius in sealed polyethylene containers. Handlers should employ deliquescence-resistant tools and maintain environmental humidity below 30%. Skin contact may cause chemical burns in presence of moisture. Inhalation may induce bronchial hyperreactivity; treatment includes anticholinergic inhalers. Eye exposure requires extended rinsing and possible corticosteroid application. Waste should be neutralized with sodium bicarbonate prior to disposal. APPLICATIONS: The 6,9-diazaspiro[4.5]decan-7-one hydrochloride serves as a key intermediate in the synthesis of various pharmaceuticals. Its spirocyclic framework provides conformational restriction that enhances receptor binding affinity. Research teams utilize this compound as a starting material for creating GABA receptor modulators and muscarinic receptor antagonists. The spirocyclic amine undergoes reductive amination for constructing tertiary amines with defined stereochemistry. Additionally, it serves as a building block for creating kinase inhibitors with enhanced metabolic stability.
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