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8-(methylsulfonyl)quinolin-3-amine; CAS No.: 347146-20-7; 8-(methylsulfonyl)quinolin-3-amine. PROPERTIES: 8-(methylsulfonyl)quinolin-3-amine is a crystalline substance with a molecular weight of 232.3 g/mol. It has a melting point between 160 and 163 C and is moderately soluble in polar organic solvents such as dimethylformamide and dimethyl sulfoxide. The compound is sensitive to light and should be stored in amber glass containers. It is stable under normal laboratory conditions but may decompose upon exposure to strong oxidizing agents. When handling, care should be taken to avoid inhalation of dust, and skin contact should be minimized. APPLICATIONS: 8-(methylsulfonyl)quinolin-3-amine serves as a valuable intermediate in the synthesis of pharmaceuticals, particularly in the development of anticancer and antiviral agents. The amine group provides a site for further functionalization, while the methylsulfonyl group enhances solubility properties. In medicinal chemistry, 8-(methylsulfonyl)quinolin-3-amine is employed in the design of compounds targeting specific protein-protein interactions. It also functions as a building block in the synthesis of fluorescent dyes, where its quinoline core contributes to emission characteristics. Additionally, the compound is used in the preparation of coordination compounds with metal ions for catalytic applications in organic transformations. These applications are commonly found in pharmaceutical research institutions and chemical manufacturing facilities specializing in heterocyclic chemistry.