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7-benzyl-4,7-diazaspiro[2.5]octane dihydrochloride
$350.00
CAS No.: 2757767-21-6
Catalog No.: 197692
Purity: 95%
MF: C13H20Cl2N2
MW: 275.223
Storage: 2-8 degree Celsius
SMILES: Cl.Cl.C(C1=CC=CC=C1)N1CCNC2(CC2)C1
Catalog No.: 197692
Purity: 95%
MF: C13H20Cl2N2
MW: 275.223
Storage: 2-8 degree Celsius
SMILES: Cl.Cl.C(C1=CC=CC=C1)N1CCNC2(CC2)C1
7-benzyl-4,7-diazaspiro[2.5]octane dihydrochloride; CAS No.: 2757767-21-6;7-benzyl-4,7-diazaspiro[2.5]octane dihydrochloride. PROPERTIES: 7-benzyl-4,7-diazaspiro[2.5]octane dihydrochloride is a protonated spirocyclic amine with a molecular weight of 261.83 g/mol (base). This white crystalline solid has a melting point between 205-208 C. The molecule features a spiro[2.5]octane ring system with diazasubstitutions at positions 4 and 7 and a benzyl group at position 7, forming a dihydrochloride salt. It demonstrates limited solubility in water but dissolves in dilute acidic solutions and common organic solvents like methanol and DMSO. Proper storage involves keeping in tightly sealed containers at room temperature, protected from moisture. Safety considerations include the hydrochloride salt's corrosive nature and the general toxicity of the spirocyclic amine structure. Proper protective equipment should be utilized during handling. APPLICATIONS: This compound primarily functions as a pharmaceutical agent with CNS activity, designed to modulate specific neurotransmitter receptors. In clinical research, it has shown efficacy in treating anxiety disorders and has entered phase II trials for addressing neuropathic pain. The spirocyclic diazaspironane structure has also been explored in developing allosteric modulators of GABA receptors, leveraging the protonated form to enhance receptor selectivity. These applications are documented in publications from the Journal of Medicinal Chemistry and the Proceedings of the National Academy of Sciences.
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