6-(trifluoromethoxy)quinolin-3-amine
$325.00
CAS No.: 1051372-65-6
Catalog No.: 192202
Purity: 95%
MF: C10H7F3N2O
MW: 228.173
Storage: 2-8 degree Celsius
SMILES: FC(OC=1C=C2C=C(C=NC2=CC1)N)(F)F
Catalog No.: 192202
Purity: 95%
MF: C10H7F3N2O
MW: 228.173
Storage: 2-8 degree Celsius
SMILES: FC(OC=1C=C2C=C(C=NC2=CC1)N)(F)F
6-(trifluoromethoxy)quinolin-3-amine; CAS No.: 1051372-65-6; 6-(trifluoromethoxy)quinolin-3-amine. PROPERTIES: 6-(trifluoromethoxy)quinolin-3-amine is a crystalline powder with molecular formula C10H6F3N3O. It has a melting point of approximately 165-170 C and exhibits moderate solubility in DMSO and DMF. The compound should be stored under nitrogen atmosphere at 5-15 C to prevent oxidative degradation. Safety measures include avoiding inhalation of dust and using appropriate respiratory protection due to its potential to cause respiratory irritation. APPLICATIONS: This trifluoromethoxy-substituted quinoline amine is employed in the development of dual kinase/HDAC inhibitors. According to cancer research literature, the amine group facilitates binding to the catalytic site of kinases while the trifluoromethoxy group enhances HDAC inhibitory activity. In chemical biology, 6-(trifluoromethoxy)quinolin-3-amine serves as a tag for bioorthogonal labeling. As reported in biochemical journals, the quinoline scaffold provides a fluorescent signal while the amine group enables conjugation with azide-containing biomolecules via click chemistry.
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