6,7-difluoroquinolin-3-amine
$450.00
CAS No.: 318684-82-1
Catalog No.: 191960
Purity: 95%
MF: C9H6F2N2
MW: 180.157
Storage: 2-8 degree Celsius
SMILES: FC=1C=C2C=C(C=NC2=CC1F)N
Catalog No.: 191960
Purity: 95%
MF: C9H6F2N2
MW: 180.157
Storage: 2-8 degree Celsius
SMILES: FC=1C=C2C=C(C=NC2=CC1F)N
6,7-difluoroquinolin-3-amine; CAS No.: 318684-82-1; 6,7-difluoroquinolin-3-amine. PROPERTIES: 6,7-difluoroquinolin-3-amine (CAS No.: 318684-82-1) presents as a white crystalline powder with a melting point between 155-158 C. The compound features fluorine atoms at positions 6 and 7 and an amine group at position 3 of the quinoline ring system. Its amine functionality exhibits moderate basicity with a pKa value around 5.0, while the fluorine substituents impart electron-withdrawing effects that enhance the compound's reactivity. Solubility characteristics reveal good dissolvability in polar organic solvents such as DMF and DMSO, while being sparingly soluble in water due to the hydrophobic aromatic system. The substance is moisture-sensitive and prone to oxidation upon prolonged exposure to air, necessitating storage in a tightly sealed container under nitrogen atmosphere at controlled temperature (15-25 C). Safety protocols recommend N95 respiratory protection, chemical-resistant gloves, and eye protection due to potential skin irritation and eye damage. The compound has a moderate vapor pressure and forms flammable mixtures with air above 50 C. APPLICATIONS: 6,7-difluoroquinolin-3-amine serves as a valuable intermediate in developing anticancer agents targeting specific protein kinases as documented in oncology research. Its fluorinated quinoline core enables the synthesis of antiviral agents with activity against RNA viruses as reported in virology literature. Additionally, 318684-82-1 contributes to the development of fluorescent probes for detecting specific protein targets in cellular environments, with several studies highlighting its utility in creating pH-sensitive indicators for monitoring endocytic processes during drug delivery. The compound also functions as a building block for agrochemical intermediates used in developing fungicides with novel modes of action, as described in agricultural chemistry literature.
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