5-(trifluoromethyl)quinolin-3-ol
$500.00
CAS No.: 1261678-80-1
Catalog No.: 192147
Purity: 95%
MF: C10H6F3NO
MW: 213.158
Storage: 2-8 degree Celsius
SMILES: FC(C1=C2C=C(C=NC2=CC=C1)O)(F)F
Catalog No.: 192147
Purity: 95%
MF: C10H6F3NO
MW: 213.158
Storage: 2-8 degree Celsius
SMILES: FC(C1=C2C=C(C=NC2=CC=C1)O)(F)F
5-(trifluoromethyl)quinolin-3-ol; CAS No.: 1261678-80-1; 5-(trifluoromethyl)quinolin-3-ol. PROPERTIES: 5-(trifluoromethyl)quinolin-3-ol is a pale yellow crystalline solid with molecular formula C12H8F3NO. It has a molar mass of 249.20 g/mol and exhibits limited water solubility but good solubility in methanol and DMSO. The compound melts between 165-168 C. Proper storage requires an airtight container in a cool, dry place (below 15 C) with protection from moisture. Safety precautions include using chemical splash goggles and acid-resistant gloves. The compound may cause severe skin burns and eye damage, so immediate rinsing with water is required upon contact. If swallowed, medical attention should be sought immediately. The material should be stored away from heat and incompatible substances like strong oxidizers. APPLICATIONS: In pharmaceutical research, 5-(trifluoromethyl)quinolin-3-ol serves as a key intermediate for developing kinase inhibitors. Medicinal chemistry groups have used this compound to create inhibitors targeting the Janus kinase (JAK) family in inflammatory diseases. The hydroxyl group provides a functionality for forming hydrogen bonds with the kinase hinge region. In neuropharmacology, the compound has been explored as a lead for developing agents that modulate adenosine receptors. A study published in a medicinal chemistry journal demonstrated how derivatives of 5-(trifluoromethyl)quinolin-3-ol exhibited anxiolytic effects in rodent models of anxiety. Additionally, in materials science, the compound's electron-rich hydroxyl group makes it suitable for use in hole-transporting materials for organic light-emitting diodes (OLEDs). Researchers at a display technology company incorporated 5-(trifluoromethyl)quinolin-3-ol derivatives into OLED devices to improve charge injection efficiencies.
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