5-methoxyisoquinoline
$250.00
CAS No.: 90806-58-9
Catalog No.: 196251
Purity: 95%
MF: C10H9NO
MW: 159.188
Storage: 2-8 degree Celsius
SMILES: COC1=C2C=CN=CC2=CC=C1
Catalog No.: 196251
Purity: 95%
MF: C10H9NO
MW: 159.188
Storage: 2-8 degree Celsius
SMILES: COC1=C2C=CN=CC2=CC=C1
5-methoxyisoquinoline; CAS No.: 90806-58-9; 5-methoxyisoquinoline. PROPERTIES: This compound presents a 5-methoxyisoquinoline structure, combining a methoxy substituent and an isoquinoline framework. It typically appears as a white to off-white crystalline solid with a molecular weight of approximately 164.2 g/mol (C9H8NO). The melting point ranges between 80-85 C, and it exhibits moderate solubility in common organic solvents like ethyl acetate, dichloromethane, and tetrahydrofuran while being sparingly soluble in water. Proper storage requires a tightly sealed container in a cool, dry place. Safety considerations include wearing appropriate PPE. It is classified as a skin and eye irritant (GHS07) with the hazard statement H315-H319. APPLICATIONS: 5-Methoxyisoquinoline serves as a specialized intermediate in pharmaceutical research. Its 5-methoxyisoquinoline structure enables diverse reactivity patterns, including nucleophilic substitution at the methoxy group and electrophilic substitution at the isoquinoline ring. In medicinal chemistry, it is used to develop bioactive molecules targeting kinases, proteases, and G protein-coupled receptors. The methoxy substituent provides steric and electronic effects that influence binding interactions with biological targets. This compound also functions as a building block in the synthesis of fluorescent dyes and bioconjugation reagents. Academic studies utilize it as a model system in Medicinal Chemistry journals, focusing on optimizing the 5-methoxyisoquinoline scaffold for improved biological activity and pharmacokinetic properties.
Reviews
Write Your Own Review