5-bromo-1-phenyl-1H-pyrazole-4-carbonitrile
$225.00
CAS No.: 76767-44-7
Catalog No.: 192881
Purity: 95%
MF: C10H6BrN3
MW: 248.083
Storage: 2-8 degree Celsius
SMILES: BrC1=C(C=NN1C1=CC=CC=C1)C#N
Catalog No.: 192881
Purity: 95%
MF: C10H6BrN3
MW: 248.083
Storage: 2-8 degree Celsius
SMILES: BrC1=C(C=NN1C1=CC=CC=C1)C#N
5-bromo-1-phenyl-1H-pyrazole-4-carbonitrile; CAS No.: 76767-44-7; 5-bromo-1-phenyl-1H-pyrazole-4-carbonitrile. PROPERTIES: This compound appears as a white to off-white crystalline solid with molecular formula C10H7BrN2 and a molecular weight of 257.08 g/mol. It demonstrates a melting point in the range of 108-112 C and shows moderate solubility in common organic solvents like dichloromethane and acetone. The substance is sensitive to photodegradation and should be stored in amber containers. Recommended storage involves maintaining in tightly sealed containers at temperatures below 20 C, protected from light and moisture. When handling, standard laboratory safety protocols should be followed, including the use of protective gloves and eye wear, as 5-bromo-1-phenyl-1H-pyrazole-4-carbonitrile may release toxic fumes upon heating. The bromo group requires careful handling in strongly basic environments. APPLICATIONS: In the pharmaceutical industry, 5-bromo-1-phenyl-1H-pyrazole-4-carbonitrile serves as an intermediate for synthesizing anticancer agents, as described in medicinal chemistry literature focusing on kinase inhibitors. Its bromo substituent enables participation in cross-coupling reactions for constructing biaryl systems. Additionally, this compound functions as a building block for preparing agrochemicals with insecticidal activities through nucleophilic aromatic substitution reactions. Academic research has explored its potential in the development of fluorescent probes for bioimaging applications, as reported in biochemical journals. The nitrile group also facilitates formation of bioactive amides through hydrolysis reactions, making it valuable for drug discovery applications, as evidenced by studies in medicinal chemistry publications.
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