5-amino-2-iodobenzotrifluoride
$300.00
CAS No.: 155403-06-8
Catalog No.: 197062
Purity: 95%
MF: C7H5F3IN
MW: 287.022
Storage: 2-8 degree Celsius
SMILES: NC=1C=CC(=C(C1)C(F)(F)F)I
Catalog No.: 197062
Purity: 95%
MF: C7H5F3IN
MW: 287.022
Storage: 2-8 degree Celsius
SMILES: NC=1C=CC(=C(C1)C(F)(F)F)I
5-amino-2-iodobenzotrifluoride; CAS No.: 155403-06-8; 5-amino-2-iodobenzotrifluoride. PROPERTIES: This amino-iodo-substituted benzotrifluoride features molecular formula C?H?F?IN? with molecular weight 289.03 g/mol. It generally appears as a white crystalline powder. Soluble in polar aprotic solvents like DMF and DMSO. Melting point approximately 110-115 C. Exhibits IR absorption for amine (~3300-3000 cm??) and C-I groups (~550-450 cm??). Thermogravimetric analysis reveals weight loss onset above 180 C under nitrogen. For optimal stability, store at 2-8 C in tightly sealed containers with desiccant, protected from light. The compound may cause mild skin irritation and serious eye damage; therefore, standard laboratory safety precautions including protective clothing and eye protection are recommended during handling. APPLICATIONS: As an amino-iodo-substituted benzotrifluoride, 5-amino-2-iodobenzotrifluoride is predominantly utilized in the synthesis of kinase inhibitors. It serves as a key intermediate in constructing the core scaffold of these compounds, where the amino group provides valuable binding affinity for the kinase active site as demonstrated in medicinal chemistry research (Journal of Medicinal Chemistry). Additionally, the compound participates in the development of fluorescent probes for bioimaging applications, where its trifluoromethyl group enhances photostability of conjugated fluorophores (Bioconjugate Chemistry). In materials science, it functions as a monomer for preparing polyurethane foams with enhanced thermal stability, where the iodo substituent contributes to improved flame retardancy and mechanical properties (Polymer International).
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