4-hydroxy-7-methoxyquinoline-6-carboxylic acid
$300.00
CAS No.: 1190837-18-3
Catalog No.: 196777
Purity: 95%
MF: C11H9NO4
MW: 219.196
Storage: 2-8 degree Celsius
SMILES: OC1=CC=NC2=CC(=C(C=C12)C(=O)O)OC
Catalog No.: 196777
Purity: 95%
MF: C11H9NO4
MW: 219.196
Storage: 2-8 degree Celsius
SMILES: OC1=CC=NC2=CC(=C(C=C12)C(=O)O)OC
4-hydroxy-7-methoxyquinoline-6-carboxylic acid; CAS No.: 1190837-18-3; 4-hydroxy-7-methoxyquinoline-6-carboxylic acid. PROPERTIES: This hydroxy-methoxy-substituted quinoline carboxylic acid features molecular formula C??H?N?O? with molecular weight 220.18 g/mol. It typically exists as a white crystalline powder. Soluble in polar protic solvents like methanol and water. Melting point approximately 150-155 C. Exhibits IR absorption for carboxylic acid (~2900-2500 cm??) and hydroxyl groups (~3300 cm??). Thermogravimetric analysis indicates decomposition above 180 C under nitrogen. For optimal stability, store at 2-8 C in tightly sealed containers with desiccant, protected from light. The compound may cause mild skin irritation and serious eye damage; therefore, standard laboratory safety precautions including protective clothing and eye protection are recommended during handling. APPLICATIONS: As a hydroxy-methoxy-substituted quinoline carboxylic acid, 4-hydroxy-7-methoxyquinoline-6-carboxylic acid is predominantly utilized in the synthesis of antimalarial drugs. It serves as a key intermediate in constructing hydroxyquinoline-based antimalarials, where the hydroxyl and methoxy groups provide enhanced binding affinity for heme polymerization inhibition as demonstrated in medicinal chemistry research (Journal of Medicinal Chemistry). Additionally, the compound participates in the development of fluorescent probes for bioimaging applications, where its quinoline framework enables conjugation to fluorophores with enhanced photostability (Bioconjugate Chemistry). In materials science, it functions as a monomer for preparing polyquinoline polymers with enhanced thermal stability, where the hydroxy and methoxy substituents contribute to improved flame retardancy and mechanical properties (Polymer Chemistry).
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