4-bromo-1-fluoro-2-(trifluoromethoxy)benzene
$300.00
CAS No.: 886496-45-3
Catalog No.: 194037
Purity: 95%
MF: C7H3BrF4O
MW: 258.996
Storage: 2-8 degree Celsius
SMILES: BrC1=CC(=C(C=C1)F)OC(F)(F)F
Catalog No.: 194037
Purity: 95%
MF: C7H3BrF4O
MW: 258.996
Storage: 2-8 degree Celsius
SMILES: BrC1=CC(=C(C=C1)F)OC(F)(F)F
4-bromo-1-fluoro-2-(trifluoromethoxy)benzene; CAS No.: 886496-45-3; 4-bromo-1-fluoro-2-(trifluoromethoxy)benzene. PROPERTIES: 4-bromo-1-fluoro-2-(trifluoromethoxy)benzene is a colorless to pale yellow liquid with a molecular weight of 250.9 g/mol. It has a boiling point ranging from 102-104 C at 10 mmHg and exhibits low water solubility while being miscible with common organic solvents such as dichloromethane, ethyl acetate, and tetrahydrofuran. The presence of bromine, fluorine, and trifluoromethoxy groups imparts significant chemical stability and distinct reactivity patterns. Proper storage requires keeping the compound in a tightly sealed container at temperatures below 20 C, protected from light and moisture. Safety precautions include using protective gloves, eye protection, and ensuring adequate ventilation during handling. The compound may cause serious eye damage and skin irritation, and appropriate first aid measures should be followed in case of exposure. APPLICATIONS: 4-bromo-1-fluoro-2-(trifluoromethoxy)benzene is extensively employed as a versatile building block in organic synthesis, particularly in the preparation of biologically active molecules. Its unique substitution pattern makes it suitable for cross-coupling reactions, enabling the synthesis of complex aromatic systems for pharmaceutical research. In the field of medicinal chemistry, it serves as a precursor to certain antidepressant and antipsychotic drugs, as described in psychopharmacology literature. The bromine substituent provides a convenient handle for further functionalization, such as Suzuki-Miyaura couplings. Additionally, the compound functions as an intermediate in the production of specialty materials, including liquid crystalline polymers, where the trifluoromethoxy group contributes to desired physical properties. Its fluorinated architecture also makes it useful in the development of agrochemicals (though non-agricultural applications are emphasized here), as reported in recent advances in fluorine chemistry.
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