4-amino-3-chloro-2-fluorobenzonitrile
$200.00
CAS No.: 2092765-25-6
Catalog No.: 194036
Purity: 95%
MF: C7H4ClFN2
MW: 170.574
Storage: 2-8 degree Celsius
SMILES: NC1=C(C(=C(C#N)C=C1)F)Cl
Catalog No.: 194036
Purity: 95%
MF: C7H4ClFN2
MW: 170.574
Storage: 2-8 degree Celsius
SMILES: NC1=C(C(=C(C#N)C=C1)F)Cl
4-amino-3-chloro-2-fluorobenzonitrile; CAS No.: 2092765-25-6; 4-amino-3-chloro-2-fluorobenzonitrile. PROPERTIES: 4-amino-3-chloro-2-fluorobenzonitrile is a crystalline solid with a molecular weight of 182.6 g/mol. It typically exhibits a melting point between 102-105 C and limited aqueous solubility, while demonstrating good solubility in common organic solvents such as dimethylformamide, dimethyl sulfoxide, and tetrahydrofuran. The compound contains reactive functional groups including an amino group, chloro substituent, fluoro substituent, and a nitrile group, which contribute to its chemical versatility. For optimal storage, it should be kept in a tightly sealed container at temperatures below 20 C, preferably under inert atmosphere to prevent potential oxidation. Safety considerations include wearing appropriate protective clothing, gloves, and eye/face protection to minimize exposure risk. The compound may cause eye irritation and skin irritation, and in case of accidental ingestion, immediate medical attention is advised. APPLICATIONS: 4-amino-3-chloro-2-fluorobenzonitrile serves as a valuable intermediate in the synthesis of various pharmaceuticals, particularly in the development of targeted kinase inhibitors for cancer therapy. Its unique substitution pattern allows for selective derivatization, making it suitable for constructing bioactive scaffolds, as reported in oncology research publications. In agrochemical applications (though non-agricultural uses are emphasized here), it functions as a precursor to certain herbicide formulations. The chloro and fluoro substituents enhance metabolic stability when incorporated into larger molecules. Additionally, the compound is utilized in the preparation of specialized fluorescent markers for bioimaging applications, where its electronic structure facilitates detection sensitivity. Through strategic functionalization of the amino group, it can be converted into various heterocyclic systems, thereby expanding its utility in medicinal chemistry and materials science, as documented in recent advances in organic synthesis.
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