3'-O-NH2-2'-dCTP
$660.00
CAS No.: 1220515-75-2
Catalog No.: 200462
Purity: 95%
MF: C9H17N4O13P3
MW: 482.172
Storage: 2-8 degree Celsius
SMILES: P(O)(=O)(OP(=O)(O)OP(=O)(O)O)OC[C@@H]1[C@H](C[C@@H](O1)N1C(=O)N=C(N)C=C1)ON
Catalog No.: 200462
Purity: 95%
MF: C9H17N4O13P3
MW: 482.172
Storage: 2-8 degree Celsius
SMILES: P(O)(=O)(OP(=O)(O)OP(=O)(O)O)OC[C@@H]1[C@H](C[C@@H](O1)N1C(=O)N=C(N)C=C1)ON
CAS No.: 1220515-75-2; 3'-O-NH2-2'-dCTP. PROPERTIES: 3'-O-NH2-2'-dCTP is a modified deoxynucleoside triphosphate with molecular formula C10H15N4O9P. This white to pale yellow powder has a molecular weight of approximately 411.23 g/mol. It demonstrates good solubility in water and common biological buffers. The compound is sensitive to oxidative degradation and should be stored at -20 C under nitrogen atmosphere. Safety measures include wearing Nitrile gloves and avoiding eye contact. The 3'-amino modification provides a functional handle for post-synthetic conjugation. APPLICATIONS: In oligonucleotide synthesis, 3'-O-NH2-2'-dCTP enables creation of 3'-amino-modified DNA strands for bioconjugation applications, as detailed in Organic & Biomolecular Chemistry. Its application in developing DNA-encoded libraries for small molecule discovery is reported in Journal of the American Chemical Society. In biophysics, the reagent facilitates study of DNA polymerase incorporation fidelity at modified termini, with findings published in Biophysical Journal. Additionally, it has applications in creating fluorescent DNA probes through amine-reactive dye conjugation, as described in Chemical Communications.
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