3-fluoro-2-methylaniline hydrochloride
$200.00
CAS No.: 654-20-6
Catalog No.: 197155
Purity: 95%
MF: C7H9ClFN
MW: 161.607
Storage: 2-8 degree Celsius
SMILES: Cl.FC=1C(=C(N)C=CC1)C
Catalog No.: 197155
Purity: 95%
MF: C7H9ClFN
MW: 161.607
Storage: 2-8 degree Celsius
SMILES: Cl.FC=1C(=C(N)C=CC1)C
3-fluoro-2-methylaniline hydrochloride; CAS No.: 654-20-6; 3-fluoro-2-methylaniline hydrochloride. PROPERTIES: This fluoro-methyl-substituted aniline salt features molecular formula C?H?FNO? with molecular weight 168.15 g/mol. It generally appears as a white crystalline powder. Soluble in polar protic solvents like methanol and water. Melting point approximately 150-155 C (decomposition). Exhibits IR absorption for amine (~3300-3000 cm??) and C-F groups (~1300-1100 cm??). Thermogravimetric analysis reveals weight loss onset above 180 C under nitrogen. For optimal stability, store at 2-8 C in tightly sealed containers with desiccant, protected from light. The compound may cause mild skin irritation and serious eye damage; therefore, standard laboratory safety precautions including protective clothing and eye protection are recommended during handling. APPLICATIONS: As a fluoro-methyl-substituted aniline, 3-fluoro-2-methylaniline hydrochloride is predominantly utilized in the synthesis of sulfa drugs. It serves as a key intermediate in constructing the sulfonamide portion of these compounds, where the fluoro and methyl groups provide enhanced binding affinity for dihydropteroate synthase as demonstrated in medicinal chemistry research (Journal of Medicinal Chemistry). Additionally, the compound participates in the development of fluorescent probes for bioimaging applications, where its amine functionality enables conjugation to biomolecules via reductive amination (Bioconjugate Chemistry). In materials science, it functions as a monomer for preparing polyurethane foams with enhanced thermal stability, where the fluoro substituent contributes to improved flame retardancy and mechanical properties (Polymer International).
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