2-amino-4-bromo-5-fluorobenzoic acid
$300.00
CAS No.: 1374208-42-0
Catalog No.: 197154
Purity: 95%
MF: C7H5BrFNO2
MW: 234.024
Storage: 2-8 degree Celsius
SMILES: NC1=C(C(=O)O)C=C(C(=C1)Br)F
Catalog No.: 197154
Purity: 95%
MF: C7H5BrFNO2
MW: 234.024
Storage: 2-8 degree Celsius
SMILES: NC1=C(C(=O)O)C=C(C(=C1)Br)F
2-amino-4-bromo-5-fluorobenzoic acid; CAS No.: 1374208-42-0; 2-amino-4-bromo-5-fluorobenzoic acid. PROPERTIES: This amino-bromo-fluoro-substituted benzoic acid features molecular formula C?H?BrFNO? with molecular weight 225.03 g/mol. It generally appears as a white crystalline powder. Soluble in polar protic solvents like methanol and water. Melting point approximately 130-135 C. Exhibits IR absorption for carboxylic acid (~2900-2500 cm??) and amine groups (~3300-3000 cm??). Thermogravimetric analysis indicates decomposition above 180 C under nitrogen. For optimal stability, store at 2-8 C in tightly sealed containers with desiccant, protected from light. The compound may cause mild skin irritation and serious eye damage; therefore, standard laboratory safety precautions including protective clothing and eye protection are recommended during handling. APPLICATIONS: As an amino-bromo-fluoro-substituted benzoic acid, 2-amino-4-bromo-5-fluorobenzoic acid is predominantly utilized in the synthesis of kinase inhibitors. It serves as a key intermediate in constructing the core scaffold of these compounds, where the amino, bromo, and fluoro groups provide valuable binding affinity for the kinase active site as demonstrated in medicinal chemistry research (Journal of Medicinal Chemistry). Additionally, the compound participates in the development of fluorescent probes for bioimaging applications, where its carboxylic acid functionality enables conjugation to biomolecules via amide bond formation (Bioconjugate Chemistry). In materials science, it functions as a monomer for preparing polyurethane foams with enhanced thermal stability, where the bromo and fluoro substituents contribute to improved flame retardancy and mechanical properties (Polymer International).
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