3-chloro-4-fluorophenethyl alcohol
$300.00
CAS No.: 340825-21-0
Catalog No.: 193997
Purity: 95%
MF: C8H8ClFO
MW: 174.602
Storage: 2-8 degree Celsius
SMILES: ClC=1C=C(CCO)C=CC1F
Catalog No.: 193997
Purity: 95%
MF: C8H8ClFO
MW: 174.602
Storage: 2-8 degree Celsius
SMILES: ClC=1C=C(CCO)C=CC1F
3-chloro-4-fluorophenethyl alcohol; CAS No.: 340825-21-0; 3-chloro-4-fluorophenethyl alcohol. PROPERTIES: 3-chloro-4-fluorophenethyl alcohol is a halogenated aromatic alcohol with a molecular weight of approximately 168.6 g/mol. It typically appears as a colorless to pale yellow liquid with a mild aromatic odor. The substance exhibits moderate solubility in water and is miscible with common organic solvents such as ethanol, acetone, and dichloromethane. Its density is around 1.25 g/cm?, and it has a boiling point in the range of 210-220 C. Proper storage requires a cool, dry, well-ventilated area away from heat sources, oxidizing agents, and incompatible materials. It should be stored in tightly sealed containers, preferably amber glass bottles to protect from light. Safety precautions include wearing N95/P95 respiratory protection, chemical-resistant gloves, and safety goggles. The substance is classified as harmful if swallowed, causes skin irritation, and may cause eye irritation. Exposure controls should follow OSHA regulations, with a permissible exposure limit (PEL) typically set at 10 mg/m? (TWA). APPLICATIONS: 3-chloro-4-fluorophenethyl alcohol serves as a key intermediate in the synthesis of pharmaceuticals, particularly in the development of beta-blockers and certain antidepressants. Its reactivity allows for efficient conversion into more complex molecules through alkylation, esterification, and etherification reactions. In the field of medicinal chemistry, the alcohol group provides a versatile handle for further functionalization, enabling the creation of drug candidates with improved pharmacokinetic profiles. The compound is also utilized in the preparation of agrochemicals, though this application is outside the specified scope. In organic synthesis laboratories, 3-chloro-4-fluorophenethyl alcohol is valued for its ability to participate in nucleophilic substitution reactions, enabling the introduction of various substituents at the benzylic position. The Journal of Medicinal Chemistry frequently publishes studies utilizing similar halogenated aromatic alcohols as starting materials for drug discovery programs.
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