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3-aminopyrrolidin-2-one hydrochloride; CAS No.: 117879-49-9; 3-aminopyrrolidin-2-one hydrochloride. PROPERTIES: This compound appears as a white crystalline powder with molecular formula C4H8N2O {HCl and a molecular weight of 128.58 g/mol. It demonstrates a melting point in the range of 198-202 C and shows good solubility in water and common polar solvents like methanol. The substance is hygroscopic and should be stored in dry conditions. Recommended storage involves maintaining in tightly sealed containers at room temperature with protection from moisture and light. When handling, standard laboratory safety precautions should be observed, including the use of gloves and eye protection, as 3-aminopyrrolidin-2-one hydrochloride may cause skin and eye irritation. The amino group requires careful handling in strongly acidic environments. APPLICATIONS: In the pharmaceutical industry, 3-aminopyrrolidin-2-one hydrochloride serves as an intermediate for synthesizing non-steroidal anti-inflammatory drugs (NSAIDs), as described in medicinal chemistry literature focusing on pyrrolidine derivatives. Its amino substituent enables formation of bioactive amides through amidation reactions. Additionally, this compound functions as a building block for preparing agrochemicals with fungicidal activities through coupling reactions. Academic research has explored its potential in metal coordination chemistry for creating luminescent sensors, as reported in inorganic chemistry journals. The pyrrolidinone ring system also facilitates formation of metal-organic frameworks (MOFs), making it valuable for gas storage applications in materials science, as evidenced by studies in crystallography publications.