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3,4-dichloro-2-fluorobenzaldehyde; CAS No.: 1349718-54-2;3,4-dichloro-2-fluorobenzaldehyde. PROPERTIES: 3,4-dichloro-2-fluorobenzaldehyde is a chlorinated and fluorinated aromatic aldehyde with molecular formula C7H4Cl2FO. It typically exists as a colorless to pale yellow liquid with a boiling point around 145-150 C. The compound has limited water solubility but dissolves well in organic solvents like dichloromethane or ether. It exhibits moderate thermal stability but may decompose when exposed to high temperatures or strong bases, releasing toxic chlorine and fluorine-containing fumes. Proper storage involves keeping it in tightly sealed containers below 25 C, protected from light and moisture. APPLICATIONS: In organic synthesis, this compound serves as a versatile building block for creating complex aromatic systems. The dichloro and fluoro substituents provide multiple sites for cross-coupling and nucleophilic substitution reactions, while the aldehyde group enables condensation reactions to form Schiff bases or other imine derivatives (The Journal of Organic Chemistry). In pharmaceutical development, 3,4-dichloro-2-fluorobenzaldehyde contributes to the synthesis of antimicrobial agents where the halogenated aromatic scaffold enhances binding to microbial targets (Antimicrobial Agents and Chemotherapy). The compound also finds application in materials science as a building block for organic electronics, where its electron-deficient aromatic core modulates the electronic properties of derived materials (Advanced Functional Materials).