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3-(trifluoromethyl)cyclobutan-1-amine hydrochloride
$300.00
CAS No.: 1803601-06-0
Catalog No.: 195562
Purity: 95%
MF: C5H9ClF3N
MW: 175.581
Storage: 2-8 degree Celsius
SMILES: Cl.FC(C1CC(C1)N)(F)F
Catalog No.: 195562
Purity: 95%
MF: C5H9ClF3N
MW: 175.581
Storage: 2-8 degree Celsius
SMILES: Cl.FC(C1CC(C1)N)(F)F
3-(trifluoromethyl)cyclobutan-1-amine hydrochloride; CAS No.: 1803601-06-0; 3-(trifluoromethyl)cyclobutan-1-amine hydrochloride. PROPERTIES: 3-(trifluoromethyl)cyclobutan-1-amine hydrochloride is a white crystalline powder with molecular formula C5H9ClF3N. It exhibits a melting point around 145-148 C and moderate thermal stability. The compound shows good solubility in water and moderate solubility in methanol. Recommended storage requires keeping it in tightly sealed containers at room temperature. Safety considerations involve avoiding skin contact with the hydrochloride salt due to potential irritation and using appropriate eye protection. APPLICATIONS: This trifluoromethyl-substituted cyclobutylamine serves as a key intermediate in the synthesis of dual NHE1/PDE10 inhibitors for cancer therapy, where the 3-(trifluoromethyl)cyclobutan-1-amine hydrochloride group provides optimal binding to both targets (Journal of Medicinal Chemistry). In chemical biology, the compound is used as a building block for developing covalent inhibitors targeting protein kinases involved in cell proliferation pathways (ACS Medicinal Chemistry Letters). Furthermore, its amine functionality enables reductive amination reactions for the preparation of diverse secondary amines used in medicinal chemistry library development (Bioorganic & Medicinal Chemistry Letters).
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