2-o-tolylpiperazine hydrochloride
$200.00
CAS No.: 161115-88-4
Catalog No.: 192784
Purity: 95%
MF: C11H17ClN2
MW: 212.724
Storage: 2-8 degree Celsius
SMILES: Cl.C1(=C(C=CC=C1)C1NCCNC1)C
Catalog No.: 192784
Purity: 95%
MF: C11H17ClN2
MW: 212.724
Storage: 2-8 degree Celsius
SMILES: Cl.C1(=C(C=CC=C1)C1NCCNC1)C
2-o-tolylpiperazine hydrochloride; CAS No.: 161115-88-4; 2-o-tolylpiperazine hydrochloride. PROPERTIES: This tolyl-substituted piperazine salt has molecular formula C11H14N2 {HCl. It appears as a white crystalline powder. The 2-o-tolylpiperazine hydrochloride exhibits high water solubility (exceeding 100 mg/mL) and moderate solubility in common polar solvents. Its melting point ranges between 190-195 C (with decomposition), and it has a molecular weight of approximately 204.69 g/mol (free base). When handling, care should be taken to avoid skin contact and use of proper respiratory protection. Storage should be in a tightly sealed container at room temperature, protected from light and moisture. The hydrochloride salt form makes it hygroscopic, requiring proper sealing during storage. In case of eye contact, immediate rinsing with water for 15 minutes is necessary. APPLICATIONS: The 2-o-tolylpiperazine hydrochloride serves as a valuable intermediate in the synthesis of serotonin receptor antagonists for psychiatric disorders where the piperazine ring provides essential hydrogen bonding interactions with receptor subtypes (as detailed in medicinal chemistry literature). The tolyl group enhances metabolic stability by preventing oxidative degradation. Additionally, the compound functions as a building block in the preparation of agrochemicals with herbicidal activity, though this application is mentioned only for informational purposes per your request. The amine group can be further functionalized through acylation or sulfonamidation reactions to produce various derivatives for chemical research applications.
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