2-nitro-5-trifluoromethoxytoluene
$180.00
CAS No.: 70692-43-2
Catalog No.: 193944
Purity: 95%
MF: C8H6F3NO3
MW: 221.134
Storage: 2-8 degree Celsius
SMILES: [N+](=O)([O-])C1=C(C)C=C(C=C1)OC(F)(F)F
Catalog No.: 193944
Purity: 95%
MF: C8H6F3NO3
MW: 221.134
Storage: 2-8 degree Celsius
SMILES: [N+](=O)([O-])C1=C(C)C=C(C=C1)OC(F)(F)F
2-nitro-5-trifluoromethoxytoluene; CAS No.: 70692-43-2;2-nitro-5-trifluoromethoxytoluene. PROPERTIES: 2-nitro-5-trifluoromethoxytoluene is a nitrated and trifluoromethylated aromatic compound with molecular formula C8H8F3NO3. It typically exists as a colorless liquid with a boiling point around 140-145 C. The compound has limited water solubility but dissolves well in organic solvents like dichloromethane or carbon tetrachloride. It exhibits moderate thermal stability but may decompose when exposed to high temperatures or strong bases, releasing toxic nitrogen oxides and fluorine-containing fumes. Proper storage involves keeping it in tightly sealed containers below 25 C, protected from light and moisture. APPLICATIONS: In organic synthesis, this compound serves as a versatile intermediate for creating complex aromatic systems. The nitro and trifluoromethoxy substituents provide strong electron-withdrawing effects that influence reactivity and selectivity, while the methyl group offers steric protection (Tetrahedron Letters). In pharmaceutical development, 2-nitro-5-trifluoromethoxytoluene contributes to the synthesis of antimicrobial agents where the halogenated aromatic scaffold enhances binding to microbial targets (Antimicrobial Agents and Chemotherapy). The compound also finds application in materials science as a building block for organic electronics, where its electron-deficient aromatic core modulates the electronic properties of derived materials (Journal of Materials Chemistry C).
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