2-hydroxy-4-methoxybenzonitrile
$250.00
CAS No.: 39835-11-5
Catalog No.: 196523
Purity: 95%
MF: C8H7NO2
MW: 149.149
Storage: 2-8 degree Celsius
SMILES: OC1=C(C#N)C=CC(=C1)OC
Catalog No.: 196523
Purity: 95%
MF: C8H7NO2
MW: 149.149
Storage: 2-8 degree Celsius
SMILES: OC1=C(C#N)C=CC(=C1)OC
2-hydroxy-4-methoxybenzonitrile; CAS No.: 39835-11-5; 2-hydroxy-4-methoxybenzonitrile. PROPERTIES: 2-hydroxy-4-methoxybenzonitrile is a white crystalline powder with a molecular formula of C9H7NO2. It has a molecular weight of 161.16 g/mol and a melting point of approximately 118-121 C. The compound exhibits moderate solubility in water and is more soluble in polar aprotic solvents like DMSO and DMF. It is sensitive to acidic conditions and should be stored in a cool, dry place at temperatures below 25 C in a tightly sealed container. Safety precautions include avoiding inhalation of dust and using gloves. It is classified as a category 3 eye irritant under GHS classification. APPLICATIONS: 2-hydroxy-4-methoxybenzonitrile serves as a key intermediate in the synthesis of various nonsteroidal anti-inflammatory drugs (NSAIDs), particularly those targeting cyclooxygenase-2 (COX-2) selectivity. Its hydroxyl and methoxy groups provide essential hydrogen bonding interactions with target enzymes. In the field of materials science, this compound is used in the preparation of polymeric materials with enhanced UV-absorbing properties, as documented in Polymer Chemistry. Additionally, it functions as a building block for the synthesis of fluorescent brightening agents for paper and textile industries, where its nitrile group participates in conjugation to enhance fluorescence properties. The compound is also employed in the development of novel electrochromic materials for smart window applications, where its ability to undergo redox reactions results in reversible color changes. Its unique electronic properties make it valuable in the synthesis of chiral ligands for asymmetric catalysis, particularly in palladium-catalyzed cross-coupling reactions.
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