2-chloro-6-(trifluoromethyl)pyrimidin-4-amine
$200.00
CAS No.: 85730-36-5
Catalog No.: 196465
Purity: 95%
MF: C5H3ClF3N3
MW: 197.547
Storage: 2-8 degree Celsius
SMILES: ClC1=NC(=CC(=N1)N)C(F)(F)F
Catalog No.: 196465
Purity: 95%
MF: C5H3ClF3N3
MW: 197.547
Storage: 2-8 degree Celsius
SMILES: ClC1=NC(=CC(=N1)N)C(F)(F)F
2-chloro-6-(trifluoromethyl)pyrimidin-4-amine; CAS No.: 85730-36-5; 2-chloro-6-(trifluoromethyl)pyrimidin-4-amine. PROPERTIES: 2-chloro-6-(trifluoromethyl)pyrimidin-4-amine features molecular formula C5H3ClF3N3 with molecular weight approximately 213.54 g/mol. It generally appears as a pale yellow solid with a reported melting point of 118-121 C. The compound demonstrates limited solubility in water but dissolves in polar aprotic solvents like DMSO. Proper storage involves keeping in a tightly sealed container at room temperature away from heat and direct sunlight. Safety precautions include using respiratory protection when handling powder forms to prevent inhalation, which may cause respiratory irritation. The amine group may react with electrophilic substances, so compatibility should be verified. In case of accidental release, absorb with inert material and dispose of properly. APPLICATIONS: 2-chloro-6-(trifluoromethyl)pyrimidin-4-amine functions as a key intermediate in the synthesis of antimicrobial agents. Its trifluoromethyl group provides valuable steric and electronic effects for receptor binding. In pharmaceutical research, it has been utilized to develop novel antibacterial compounds targeting resistant Gram-negative pathogens, as reported in medicinal chemistry journals focusing on infectious disease treatments. The chloro substituent provides valuable reactivity for further chemical modification. Additionally, this compound serves as a building block for veterinary pharmaceuticals, with applications described in veterinary medicinal chemistry literature focusing on antiparasitic agents.
Reviews
Write Your Own Review