2-chloro-5-(trifluoromethoxy)benzyl alcohol
$200.00
CAS No.: 1261483-31-1
Catalog No.: 193925
Purity: 95%
MF: C8H6ClF3O2
MW: 226.581
Storage: 2-8 degree Celsius
SMILES: ClC1=C(CO)C=C(C=C1)OC(F)(F)F
Catalog No.: 193925
Purity: 95%
MF: C8H6ClF3O2
MW: 226.581
Storage: 2-8 degree Celsius
SMILES: ClC1=C(CO)C=C(C=C1)OC(F)(F)F
2-chloro-5-(trifluoromethoxy)benzyl alcohol; CAS No.: 1261483-31-1;2-chloro-5-(trifluoromethoxy)benzyl alcohol. PROPERTIES: 2-chloro-5-(trifluoromethoxy)benzyl alcohol is a chlorinated and trifluoromethylated aromatic alcohol with molecular formula C8H7ClF3O2. It typically exists as a colorless liquid with a boiling point around 135-140 C. The compound has limited water solubility but dissolves well in organic solvents like dichloromethane or THF. It exhibits moderate thermal stability but may decompose when exposed to high temperatures or strong acids, releasing toxic chlorine-containing fumes. Proper storage involves keeping it in tightly sealed containers below 20 C, protected from light and moisture. APPLICATIONS: In organic synthesis, this compound serves as a versatile intermediate for creating complex aromatic molecules. The chloro substituent provides a site for cross-coupling reactions to form biaryl structures, while the trifluoromethoxy and hydroxyl groups offer additional functionality for further elaboration (The Journal of Organic Chemistry). In pharmaceutical development, 2-chloro-5-(trifluoromethoxy)benzyl alcohol contributes to the synthesis of antimicrobial agents where the halogenated aromatic scaffold enhances binding to microbial targets (Antimicrobial Agents and Chemotherapy). The compound also finds application in materials science as a building block for organic electronics, where its electron-deficient aromatic core modulates the electronic properties of derived materials (Advanced Materials).
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