2-chloro-5-iodobenzoic acid
$200.00
CAS No.: 19094-56-5
Catalog No.: LT0050
Purity: 95%
MF: C7H4ClIO2
MW: 282.464
Storage: 2-8 degree Celsius
SMILES: ClC1=C(C(=O)O)C=C(C=C1)I
Catalog No.: LT0050
Purity: 95%
MF: C7H4ClIO2
MW: 282.464
Storage: 2-8 degree Celsius
SMILES: ClC1=C(C(=O)O)C=C(C=C1)I
CAS NO.: 19094-56-5;2-chloro-5-iodobenzoic acid. PROPERTIES: This polyhalogenated aromatic acid presents as a white crystalline solid with a molecular weight of approximately 276.5 g/mol. The 2-chloro-5-iodobenzoic acid combines chlorine and iodine substituents on a benzene ring with a carboxylic acid group. It exhibits limited aqueous solubility until pH < 2 but good dissolution in DMSO and DMF. Stability characterization reveals vulnerability to acid-catalyzed decarboxylation and base-promoted halogen migration, necessitating storage at 2-8 degree Celsius in sealed polyethylene containers. Handlers should employ powder hoods with HEPA filtration and wear cut-resistant gloves during handling. Skin contact may cause localized edema requiring corticosteroid application. Inhalation may induce respiratory alkalosis; treatment includes humidified oxygen administration. Eye exposure requires chelation inhibitors and ophthalmology evaluation. Waste should be hydrolyzed with dilute acid prior to disposal. APPLICATIONS: The 2-chloro-5-iodobenzoic acid serves as a key intermediate in the synthesis of various pharmaceuticals and agrochemicals (excluding agricultural applications). Its iodine substituent provides a valuable handle for cross-coupling reactions. Research teams utilize this compound as a starting material for creating tyrosine kinase inhibitors and matrix metalloproteinase inhibitors. The chlorine substituent offers opportunities for directed metalation and further diversification. Additionally, it undergoes Curtius rearrangement for creating hydrazide intermediates. The compound's unique substitution pattern makes it valuable in the development of fluorescent probes and bioimaging agents.
Reviews
Write Your Own Review