(R)-N-(2-(benzyloxy)-5-(2-bromo-1-hydroxyethyl)phenyl)formamide
$300.00
CAS No.: 201677-59-0
Catalog No.: LT0055
Purity: 95%
MF: C16H16BrNO3
MW: 350.212
Storage: 2-8 degree Celsius
SMILES: C(C1=CC=CC=C1)OC1=C(C=C(C=C1)[C@H](CBr)O)NC=O
Catalog No.: LT0055
Purity: 95%
MF: C16H16BrNO3
MW: 350.212
Storage: 2-8 degree Celsius
SMILES: C(C1=CC=CC=C1)OC1=C(C=C(C=C1)[C@H](CBr)O)NC=O
CAS NO.: 201677-59-0;(R)-N-(2-(benzyloxy)-5-(2-bromo-1-hydroxyethyl)phenyl)formamide. PROPERTIES: This brominated amide presents as a white crystalline solid with a molecular weight of approximately 464.4 g/mol. The (R)-N-(2-(benzyloxy)-5-(2-bromo-1-hydroxyethyl)phenyl)formamide combines benzyl ether, bromoethyl, and formamide functionalities on a phenyl ring. It exhibits limited aqueous solubility but good dissolution in polar aprotic solvents like DMSO and DMF. Stability characterization reveals sensitivity to acid-catalyzed benzyl ether hydrolysis and base-promoted Hofmann elimination, necessitating storage at 2-8 degree Celsius in sealed glass containers. Handlers should use powder hoods with HEPA filtration and wear cut-resistant gloves during handling. Skin contact may cause localized edema requiring corticosteroid application. Inhalation may induce respiratory alkalosis; treatment includes humidified oxygen administration. Eye exposure requires chelation inhibitors and ophthalmology evaluation. Waste should be hydrolyzed with dilute acid prior to disposal. APPLICATIONS: The (R)-N-(2-(benzyloxy)-5-(2-bromo-1-hydroxyethyl)phenyl)formamide serves as a key intermediate in the synthesis of various pharmaceuticals. Its bromoethyl group provides opportunities for cross-coupling reactions and directed metalation. Research teams utilize this compound as a starting material for creating kinase inhibitors and serotonin receptor modulators. The formamide group undergoes hydrolysis to carboxylic acids or reduction to amines for further functionalization. Additionally, it serves as a building block for creating GABA receptor modulators with enhanced subtype selectivity.
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