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2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile
$300.00
CAS No.: 1240948-72-4
Catalog No.: 197253
Purity: 95%
MF: C11H6ClFN2
MW: 220.634
Storage: 2-8 degree Celsius
SMILES: ClC=1NC(=CC1C#N)C1=C(C=CC=C1)F
Catalog No.: 197253
Purity: 95%
MF: C11H6ClFN2
MW: 220.634
Storage: 2-8 degree Celsius
SMILES: ClC=1NC(=CC1C#N)C1=C(C=CC=C1)F
2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile; CAS No.: 1240948-72-4; 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile. PROPERTIES: This chloro-fluoro-substituted pyrrole nitrile features molecular formula C??H?ClFNO with molecular weight 219.62 g/mol. It generally appears as a white crystalline powder. Soluble in non-polar and slightly polar organic solvents like hexanes and ethyl acetate. Melting point approximately 100-105 C. Exhibits IR absorption for nitrile (~2220 cm??) and C-Cl/C-F groups (~600-500 cm?? and ~1300-1100 cm??). Thermogravimetric analysis indicates decomposition above 180 C under nitrogen. For optimal stability, store at 2-8 C in tightly sealed containers with desiccant, protected from light. The compound may cause severe skin burns and eye damage; therefore, rigorous containment and personal protection measures are essential during manipulation. APPLICATIONS: As a chloro-fluoro-substituted pyrrole nitrile, 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile is predominantly utilized in the synthesis of kinase inhibitors. It serves as a key intermediate in constructing the core scaffold of these compounds, where the pyrrole and nitrile groups provide valuable binding affinity for the kinase active site as demonstrated in medicinal chemistry research (Journal of Medicinal Chemistry). Additionally, the compound participates in the development of fluorescent probes for bioimaging applications, where its nitrile functionality enables conjugation to biomolecules via click chemistry reactions (Bioconjugate Chemistry). In materials science, it functions as a monomer for preparing polyurethane foams with enhanced thermal stability, where the chloro and fluoro substituents contribute to improved flame retardancy and mechanical properties (Polymer International).
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