(1R,2R)-1,2-diphenylethane-1,2-diol; CAS No.: 52340-78-0; (1R,2R)-1,2-diphenylethane-1,2-diol. PROPERTIES: (1R,2R)-1,2-diphenylethane-1,2-diol appears as a white to off-white crystalline powder. Its molecular formula is C14H14O2, corresponding to a molecular weight of 214.26 g/mol. The compound demonstrates moderate solubility in common organic solvents such as methanol, ethyl acetate, and dichloromethane, but limited water solubility. It has a melting point typically ranging from 115-120 C and is stable under normal laboratory conditions when stored properly. Recommended storage involves keeping the material in a tightly sealed container at room temperature (15-25 C), preferably in a cool, dry, and well-ventilated area away from direct sunlight and moisture. The compound is hygroscopic to some extent and should be protected from excessive humidity. Safety precautions include wearing appropriate personal protective equipment such as chemical-resistant gloves and eye protection when handling the material. In case of skin contact, washing with soap and water is advised, and eye contact requires thorough rinsing with water for at least 15 minutes followed by medical attention if irritation persists. The compound should be handled in well-ventilated areas to avoid inhalation of dust particles. APPLICATIONS: (1R,2R)-1,2-diphenylethane-1,2-diol serves as a valuable chiral building block in organic synthesis, particularly in the preparation of bioactive molecules and pharmaceutical intermediates. Its unique stereochemistry makes it suitable for constructing complex architectures in drug discovery pipelines. In medicinal chemistry, the compound has been utilized in the synthesis of novel cardiovascular agents and as a chiral scaffold for combinatorial library synthesis, as documented in several pharmaceutical research journals. The diphenylethylene framework provides a suitable platform for the development of enzyme inhibitors and receptor modulators with improved pharmacokinetic profiles. Additionally, (1R,2R)-1,2-diphenylethane-1,2-diol finds application in materials science as a chiral auxiliary in asymmetric catalysis and as a component in liquid crystal applications. Its utility extends to analytical chemistry, where it serves as a reference compound for chiral separation techniques and as a starting material for custom syntheses in specialized laboratories focusing on stereochemistry and medicinal applications. The compound's structural features make it suitable for incorporation into molecular sensors and as a component in chiral recognition studies.