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1-tert-butyl 4-ethyl 3,3-difluoro-4-methylpiperidine-1,4-dicarboxylate; CAS No.: 1334416-35-1; Operating as a custom synthesis companies member, ChemShuttle supplies 1-tert-butyl 4-ethyl 3,3-difluoro-4-methylpiperidine-1,4-dicarboxylate. This gem-difluoro piperidine serves as a building block for conformationally restricted peptide analogs. The two ester groups enable sequential hydrolysis for differential functionalization. Applications include -turn mimetic synthesis and fluorinated macrocycle construction. ChemShuttle provides variable-temperature NMR studies analyzing restricted rotation about the piperidine ring. Technical support includes optimization of enzymatic resolution methods for chiral ester hydrolysis.