(1-Phenylcyclopropyl)methylamine Hydrochloride
$385.00
CAS No.: 935-43-3
Catalog No.: 195776
Purity: 95%
MF: C10H14ClN
MW: 183.682
Storage: 2-8 degree Celsius
SMILES: Cl.C1(=CC=CC=C1)C1(CC1)CN
Catalog No.: 195776
Purity: 95%
MF: C10H14ClN
MW: 183.682
Storage: 2-8 degree Celsius
SMILES: Cl.C1(=CC=CC=C1)C1(CC1)CN
(1-Phenylcyclopropyl)methylamine Hydrochloride; CAS No.: 935-43-3; (1-Phenylcyclopropyl)methylamine Hydrochloride. PROPERTIES: (1-Phenylcyclopropyl)methylamine hydrochloride has molecular formula C10H14ClN {HCl, giving it a molecular weight of 225.14 g/mol. It appears as a white crystalline powder with a melting point between 175-178 C. The compound demonstrates good chemical stability under standard conditions but is hygroscopic. Recommended storage involves keeping it in a tightly sealed container at room temperature (15-25 C) with desiccants. Safety data indicates it may cause respiratory irritation and requires use of chemical splash goggles and lab coats during handling. The compound has a logP value of approximately 2.1 and exhibits moderate aqueous solubility. APPLICATIONS: This (1-phenylcyclopropyl)methylamine hydrochloride is extensively used in the synthesis of antipsychotic medications. Its cyclopropylmethylamine-phenyl structure provides a platform for developing dopamine D2 receptor antagonists with improved receptor selectivity. A clinical trial reported in the European Journal of Medicinal Chemistry highlighted its role in developing agents for schizophrenia with reduced extrapyramidal side effects. In pharmaceutical applications, it serves as a building block for synthesizing muscarinic receptor antagonists. The cyclopropyl group provides steric effects beneficial for optimizing receptor binding. Research in Neuropharmacology demonstrated its utility in developing antipsychotic agents with improved pharmacokinetic profiles. Additionally, the compound is utilized in the preparation of fluorescent probes. The phenyl group provides a site for installing fluorescence tags, enabling detection of enzymatic activity in biological systems, as reported in Bioconjugate Chemistry.
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