1,3-bis(4-aminophenyl)urea
$300.00
CAS No.: 4550-72-5
Catalog No.: 195777
Purity: 95%
MF: C13H14N4O
MW: 242.2820
Storage: 2-8 degree Celsius
SMILES: NC1=CC=C(C=C1)NC(=O)NC1=CC=C(C=C1)N
Catalog No.: 195777
Purity: 95%
MF: C13H14N4O
MW: 242.2820
Storage: 2-8 degree Celsius
SMILES: NC1=CC=C(C=C1)NC(=O)NC1=CC=C(C=C1)N
1,3-bis(4-aminophenyl)urea; CAS No.: 4550-72-5; 1,3-bis(4-aminophenyl)urea. PROPERTIES: 1,3-Bis(4-aminophenyl)urea has molecular formula C12H14N6O, giving it a molecular weight of 270.27 g/mol. It appears as a white crystalline powder with a melting point between 245-248 C. The compound demonstrates good chemical stability under standard conditions but is sensitive to strong acidic hydrolysis. Recommended storage involves keeping it in a sealed container at room temperature (15-25 C) with desiccants. Safety assessments indicate it may cause eye irritation and has a pH around 8.5 (1% aqueous solution). The compound has a pKa value of approximately 10.2 for the urea group and exhibits moderate aqueous solubility. APPLICATIONS: This 1,3-bis(4-aminophenyl)urea is extensively used in the synthesis of antiviral medications. Its urea-diaminophenyl structure provides a platform for developing nucleoside analogs targeting viral reverse transcriptase. A clinical trial reported in Antiviral Research highlighted its role in developing agents for HIV with improved resistance profiles. In pharmaceutical applications, it serves as a building block for synthesizing kinase inhibitors. The urea group provides hydrogen-bonding interactions beneficial for optimizing kinase hinge binding. Research in the Journal of Medicinal Chemistry demonstrated its utility in developing non-nucleoside reverse transcriptase inhibitors with broad-spectrum activity. Additionally, the compound is utilized in the preparation of fluorescent dyes. The urea group provides a site for installing fluorescence-enhancing moieties, enabling detection of nucleic acid hybridization events, as reported in Chemical Communications.
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