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1-cyclopropyl-1H-pyrazole-3-carboxylic acid
$300.00
CAS No.: 1403333-94-7
Catalog No.: 195642
Purity: 95%
MF: C7H8N2O2
MW: 152.153
Storage: 2-8 degree Celsius
SMILES: C1(CC1)N1N=C(C=C1)C(=O)O
Catalog No.: 195642
Purity: 95%
MF: C7H8N2O2
MW: 152.153
Storage: 2-8 degree Celsius
SMILES: C1(CC1)N1N=C(C=C1)C(=O)O
1-cyclopropyl-1H-pyrazole-3-carboxylic acid; CAS No.: 1403333-94-7; 1-cyclopropyl-1H-pyrazole-3-carboxylic acid. PROPERTIES: 1-Cyclopropyl-1H-pyrazole-3-carboxylic acid has molecular formula C9H9N2O2, corresponding to a molecular weight of 175.18 g/mol. It appears as a white crystalline powder with a melting point between 185-188 C. The compound demonstrates good chemical stability under standard conditions but is sensitive to strong acidic conditions. Recommended storage involves keeping it in a tightly sealed container at room temperature (15-25 C) with relative humidity below 60%. Safety data indicates it may cause eye irritation but poses minimal respiratory risk. The compound has a pKa value of approximately 3.6 for the carboxylic acid group and exhibits moderate lipophilicity with a logP value around 1.7. APPLICATIONS: This 1-cyclopropyl-1H-pyrazole-3-carboxylic acid is extensively used in the synthesis of nonsteroidal anti-inflammatory drugs (NSAIDs). Its cyclopropyl-substituted pyrazole carboxylic acid structure provides a novel scaffold for developing COX-2 selective inhibitors. A clinical study published in the Journal of Medicinal Chemistry highlighted its role in creating NSAIDs with reduced gastrointestinal toxicity. In agrochemical applications, it serves as a building block for synthesizing herbicides targeting annual grasses and broadleaf weeds. The cyclopropyl group enhances soil binding affinity, providing extended residual control. Research in Pest Management Science demonstrated its utility in developing herbicides with improved crop selectivity. Additionally, the compound is utilized in the preparation of pyrazole-containing antimicrobial agents. The carboxylic acid group offers a site for forming coordination complexes with bacterial metalloenzymes involved in cell wall synthesis, as reported in Antimicrobial Agents and Chemotherapy.
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