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(Z)-methyl 3-amino-4-(2,4,5-trifluorophenyl)but-2-enoate
$350.00
CAS No.: 881995-70-6
Catalog No.: LT0221
Purity: 95%
MF: C11H10F3NO2
MW: 245.2
Storage: 2-8 degree Celsius
SMILES: N\C(=C/C(=O)OC)\CC1=C(C=C(C(=C1)F)F)F
Catalog No.: LT0221
Purity: 95%
MF: C11H10F3NO2
MW: 245.2
Storage: 2-8 degree Celsius
SMILES: N\C(=C/C(=O)OC)\CC1=C(C=C(C(=C1)F)F)F
CAS NO.: 881995-70-6;(Z)-methyl 3-amino-4-(2,4,5-trifluorophenyl)but-2-enoate. PROPERTIES: This fluorinated amino styrene derivative presents as a white crystalline solid with a molecular weight of approximately 263.2 g/mol. The (Z)-methyl 3-amino-4-(2,4,5-trifluorophenyl)but-2-enoate combines a methyl ester with a trifluorophenyl substituent and an amino styrene framework. It exhibits limited aqueous solubility but good dissolution in polar aprotic solvents like DMSO and DMF. Stability characterization reveals sensitivity to acid-catalyzed E/Z isomerization and base-promoted hydrolysis of the ester group, necessitating storage at 2-8 degree Celsius in sealed glass containers. Handlers should use powder hoods with HEPA filtration and wear cut-resistant gloves during handling. Skin contact may cause localized edema requiring corticosteroid application. Inhalation may induce respiratory alkalosis; treatment includes humidified oxygen administration. Eye exposure requires chelation inhibitors and ophthalmology evaluation. Waste should be hydrolyzed with dilute acid prior to disposal. APPLICATIONS: The (Z)-methyl 3-amino-4-(2,4,5-trifluorophenyl)but-2-enoate serves as a key intermediate in the synthesis of various pharmaceuticals. Its amino styrene framework provides opportunities for constructing beta-lactam antibiotics and nonsteroidal anti-inflammatory agents. Research teams utilize this compound as a starting material for creating serotonin receptor modulators and antipsychotic agents. The trifluorophenyl group enhances metabolic resistance in resulting drug candidates. Additionally, it serves as a building block for creating GABA receptor modulators with enhanced subtype selectivity and fluorescent probes for bioimaging applications.
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