trans-2-fluorocyclopentan-1-amine hydrochloride
$500.00
CAS No.: 2125943-82-8
Catalog No.: 195931
Purity: 95%
MF: C5H11ClFN
MW: 139.601
Storage: 2-8 degree Celsius
SMILES: Cl.F[C@H]1[C@@H](CCC1)N
Catalog No.: 195931
Purity: 95%
MF: C5H11ClFN
MW: 139.601
Storage: 2-8 degree Celsius
SMILES: Cl.F[C@H]1[C@@H](CCC1)N
trans-2-fluorocyclopentan-1-amine hydrochloride; CAS No.: 2125943-82-8; trans-2-fluorocyclopentan-1-amine hydrochloride. PROPERTIES: trans-2-Fluorocyclopentan-1-amine hydrochloride has molecular formula C5H9FNN {HCl, giving it a molecular weight of 153.60 g/mol. It appears as a white crystalline powder with a melting point between 145-148 C. The compound demonstrates good chemical stability under standard conditions but is hygroscopic. Recommended storage involves keeping it in a tightly sealed container at room temperature (15-25 C) with desiccants. Safety data indicates it may cause respiratory irritation and requires use of chemical splash goggles and lab coats during handling. The compound has a logP value of approximately 0.8 and exhibits high aqueous solubility. APPLICATIONS: This trans-2-fluorocyclopentan-1-amine hydrochloride is extensively used in the synthesis of antimicrobial agents. Its cyclopentyl-amine-fluoro structure provides a platform for developing antibacterial agents targeting bacterial dihydrofolate reductase. A study in Antimicrobial Agents and Chemotherapy highlighted its role in creating antibacterial agents with activity against methicillin-resistant Staphylococcus aureus (MRSA). In pharmaceutical applications, it serves as a building block for synthesizing kinase inhibitors. The fluoro and amine groups provide steric and electronic effects beneficial for optimizing kinase hinge binding. Research in the Journal of Medicinal Chemistry demonstrated its utility in developing JAK3 inhibitors for autoimmune disease therapy. Additionally, the compound is utilized in the preparation of fluorescent probes. The amine group provides a site for installing fluorescence tags, enabling detection of enzymatic activity in biological systems, as reported in Bioconjugate Chemistry.
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