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tert-butyl3,3-dimethyl-1-oxa-6-azaspiro[3.3]heptane-6-carboxylate
$360.00
CAS No.: 936850-12-3
Catalog No.: 197695
Purity: 95%
MF: C12H21NO3
MW: 227.304
Storage: 2-8 degree Celsius
SMILES: C(C)(C)(C)OC(=O)N1CC2(C(CO2)(C)C)C1
Catalog No.: 197695
Purity: 95%
MF: C12H21NO3
MW: 227.304
Storage: 2-8 degree Celsius
SMILES: C(C)(C)(C)OC(=O)N1CC2(C(CO2)(C)C)C1
tert-butyl3,3-dimethyl-1-oxa-6-azaspiro[3.3]heptane-6-carboxylate; CAS No.: 936850-12-3;tert-butyl3,3-dimethyl-1-oxa-6-azaspiro[3.3]heptane-6-carboxylate. PROPERTIES: tert-butyl3,3-dimethyl-1-oxa-6-azaspiro[3.3]heptane-6-carboxylate is a protected spirocyclic amine with a molecular weight of 237.27 g/mol. This white crystalline solid has a melting point between 125-128 C. The molecule features a spiro[3.3]heptane ring system with an oxasubstitution at position 1, an azasubstitution at position 6, dimethyl groups at position 3, and a tert-butyl carbamate protecting group at position 6. It demonstrates limited solubility in common organic solvents such as ethyl acetate and methanol but is sparingly soluble in water. Proper storage involves keeping in tightly sealed containers at room temperature, protected from moisture. Safety considerations include the carbamate group's potential to release isocyanate under acidic conditions and the spirocyclic structure's general toxicity. Standard laboratory safety protocols should be observed. APPLICATIONS: This compound primarily functions as a synthetic intermediate in the production of agrochemicals and pharmaceuticals, where the spirocyclic scaffold provides structural diversity for receptor interactions. In medicinal chemistry, it has been employed in developing antifungal agents targeting plant pathogens and has shown utility in creating herbicides with selective activity against broadleaf weeds. The spirocyclic oxazaspiroheptane structure has also been explored in materials science for developing chiral ligands in asymmetric catalysis, leveraging the dimethyl groups' steric effects. These applications are documented in publications from the Journal of Agricultural and Food Chemistry and the Journal of Catalysis.
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