tert-butyl 4-(aminomethyl)-2-methylpiperidine-1-carboxylate
$300.00
CAS No.: 1540186-79-5
Catalog No.: 195612
Purity: 95%
MF: C12H24N2O2
MW: 228.336
Storage: 2-8 degree Celsius
SMILES: NCC1CC(N(CC1)C(=O)OC(C)(C)C)C
Catalog No.: 195612
Purity: 95%
MF: C12H24N2O2
MW: 228.336
Storage: 2-8 degree Celsius
SMILES: NCC1CC(N(CC1)C(=O)OC(C)(C)C)C
tert-butyl 4-(aminomethyl)-2-methylpiperidine-1-carboxylate; CAS No.: 1540186-79-5; tert-butyl 4-(aminomethyl)-2-methylpiperidine-1-carboxylate. PROPERTIES: tert-butyl 4-(aminomethyl)-2-methylpiperidine-1-carboxylate is a piperidine derivative with a molecular weight of approximately 240.3 g/mol. This compound typically exists as a colorless oil with moderate viscosity and demonstrates good solubility in common organic solvents. It is sensitive to both moisture and temperature fluctuations, necessitating storage in a tightly sealed container at temperatures between 0-5 C. Special handling precautions include avoiding exposure to strong acids and bases, as the aminomethyl group may undergo protonation or alkylation reactions. The compound presents moderate acute toxicity via inhalation routes. APPLICATIONS: tert-butyl 4-(aminomethyl)-2-methylpiperidine-1-carboxylate functions as a protected piperidine building block in medicinal chemistry. The aminomethyl group provides a versatile handle for forming amide, urea, and hydantoin linkages. In pharmaceutical synthesis, this compound has been employed in the preparation of angiotensin II receptor antagonists where the piperidine ring contributes to receptor binding (source: Journal of Medicinal Chemistry). Additionally, its application extends to the synthesis of respiratory drugs, where the methyl substitution influences receptor subtype selectivity (source: European Journal of Pharmacology). The compound's utility in reductive amination reactions further enhances its application in forming N-substituted piperidine derivatives (source: Organic & Biomolecular Chemistry).
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