tert-Butyl 3-(aminomethyl)piperazine-1-carboxylate
$200.00
CAS No.: 1376099-80-7
Catalog No.: 192781
Purity: 95%
MF: C10H21N3O2
MW: 215.297
Storage: 2-8 degree Celsius
SMILES: NCC1CN(CCN1)C(=O)OC(C)(C)C
Catalog No.: 192781
Purity: 95%
MF: C10H21N3O2
MW: 215.297
Storage: 2-8 degree Celsius
SMILES: NCC1CN(CCN1)C(=O)OC(C)(C)C
tert-Butyl 3-(aminomethyl)piperazine-1-carboxylate; CAS No.: 1376099-80-7; tert-Butyl 3-(aminomethyl)piperazine-1-carboxylate. PROPERTIES: This aminomethyl-substituted piperazine carbamate has molecular formula C11H21N3O2. It appears as a white crystalline powder. The tert-Butyl 3-(aminomethyl)piperazine-1-carboxylate demonstrates limited solubility in water but good solubility in common organic solvents like methanol and ethyl acetate. Its melting point ranges between 100-105 C, and it has a molecular weight of approximately 233.31 g/mol. When handling, care should be taken to avoid skin contact and use of proper respiratory protection. Storage should be in a tightly sealed container at room temperature, protected from light and moisture. The compound is sensitive to strong acids and may undergo carbamate hydrolysis upon exposure to aqueous conditions. In case of spillage, absorb with inert material and dispose of in accordance with local regulations. APPLICATIONS: The tert-Butyl 3-(aminomethyl)piperazine-1-carboxylate functions as a key intermediate in the synthesis of serotonin receptor antagonists for psychiatric disorders where the piperazine ring provides essential hydrogen bonding interactions with receptor subtypes (as reported in medicinal chemistry literature). The aminomethyl group forms additional hydrogen bonds with receptor residues. Additionally, the compound serves as a building block in the preparation of chiral ligands for asymmetric catalysis, achieving enantiomeric excesses above 95% in certain hydrogenation reactions as described in synthetic chemistry journals. The carbamate group can be further functionalized through hydrolysis or alkylation reactions to produce various derivatives for chemical research applications.
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