tert-butyl 3,3-difluoro-4-formyl-4-methylpiperidine-1-carboxylate; CAS No.: 1400765-53-8; Operating as a chemical synthesis company, ChemShuttle provides tert-butyl 3,3-difluoro-4-formyl-4-methylpiperidine-1-carboxylate. This difluorinated piperidine aldehyde serves as a key intermediate for macrocycle synthesis via reductive amination. The formyl group enables condensation with amines to form imine linkages for subsequent reduction. Applications include fluorinated crown ethers and ion channel modulators. ChemShuttle provides reaction optimization data using various reducing agents. Technical support includes guidance on controlling macrocycle size through spacer design.