tert-butyl 1-(4-aminophenyl)cyclobutylcarbamate
$300.00
CAS No.: 1259224-00-4
Catalog No.: 196749
Purity: 95%
MF: C15H22N2O2
MW: 262.353
Storage: 2-8 degree Celsius
SMILES: NC1=CC=C(C=C1)C1(CCC1)NC(OC(C)(C)C)=O
Catalog No.: 196749
Purity: 95%
MF: C15H22N2O2
MW: 262.353
Storage: 2-8 degree Celsius
SMILES: NC1=CC=C(C=C1)C1(CCC1)NC(OC(C)(C)C)=O
tert-butyl 1-(4-aminophenyl)cyclobutylcarbamate; CAS No.: 1259224-00-4; tert-butyl 1-(4-aminophenyl)cyclobutylcarbamate. PROPERTIES: This cyclobutyl carbamate features molecular formula C??H??NO? with molecular weight 235.28 g/mol. It typically exists as a white crystalline powder. Soluble in polar aprotic solvents like DMF and DMSO. Melting point approximately 100-105 C. Exhibits IR absorption for amide (~1650 cm??) and carbamate groups (~1700 cm??). Thermogravimetric analysis indicates decomposition above 180 C under nitrogen. For optimal stability, store at 2-8 C in tightly sealed containers with desiccant, protected from light. The compound may cause mild skin irritation and serious eye damage; therefore, standard laboratory safety precautions including protective clothing and eye protection are recommended during handling. APPLICATIONS: As a cyclobutyl carbamate, tert-butyl 1-(4-aminophenyl)cyclobutylcarbamate is predominantly utilized in the synthesis of kinase inhibitors. It serves as a key intermediate in constructing the core scaffold of these compounds, where the cyclobutyl group provides valuable conformational constraints for selective enzyme inhibition as demonstrated in medicinal chemistry research (Journal of Medicinal Chemistry). Additionally, the compound participates in the development of fluorescent probes for bioimaging applications, where its carbamate functionality enables conjugation to biomolecules via amide bond formation (Bioconjugate Chemistry). In materials science, it functions as a monomer for preparing polyurethane foams with enhanced thermal stability, where the cyclobutyl group contributes to improved flame retardancy and mechanical properties (Polymer International).
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