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rel-(1R,2S)-2-Aminocyclopentanecarboxamide hydrochloride; CAS No.: 494209-39-1; rel-(1R,2S)-2-Aminocyclopentanecarboxamide hydrochloride. PROPERTIES: This chiral aminocyclopentanecarboxamide salt has molecular formula C6H12N2O {HCl. It typically appears as a white crystalline powder. The rel-(1R,2S)-2-Aminocyclopentanecarboxamide hydrochloride exhibits high water solubility (exceeding 100 mg/mL) and moderate solubility in common polar solvents. Its melting point ranges between 210-215 C (with decomposition), and it has a molecular weight of approximately 164.63 g/mol (free base). When handling, care should be taken to avoid skin contact and use of proper respiratory protection. Storage should be in a tightly sealed container at room temperature, protected from light and moisture. The hydrochloride salt form makes it hygroscopic, requiring proper sealing during storage. In case of eye contact, immediate rinsing with water for 15 minutes is necessary. APPLICATIONS: The rel-(1R,2S)-2-Aminocyclopentanecarboxamide hydrochloride functions as a key intermediate in the synthesis of HIV protease inhibitors where the aminocyclopentane ring provides essential structural features for enzyme binding (as detailed in medicinal chemistry literature). The carboxamide group forms hydrogen bonds with catalytic residues. Additionally, the compound serves as a building block in the preparation of bioconjugates for drug delivery systems where the amine group reacts with targeting moieties, as described in pharmaceutical sciences journals. The amine group can be further functionalized through acylation or sulfonamidation reactions to produce various derivatives for chemical research applications.