XL177A
$480.00
CAS No.: 2417089-74-6
Catalog No.: 193694
Purity: 95%
MF: C48H57ClN8O5
MW: 861.488
Storage: 2-8 degree Celsius
SMILES: C(C1=CC=CC=C1)[C@H](CCCNC(=O)C=1C=CC2=C(C=3CCCCC3N=C2C1)Cl)C(=O)N1CCC(CC1)(CN1C=NC2=CC(=CC=C2C1=O)NC(CCN1CCN(CC1)C)=O)O
Catalog No.: 193694
Purity: 95%
MF: C48H57ClN8O5
MW: 861.488
Storage: 2-8 degree Celsius
SMILES: C(C1=CC=CC=C1)[C@H](CCCNC(=O)C=1C=CC2=C(C=3CCCCC3N=C2C1)Cl)C(=O)N1CCC(CC1)(CN1C=NC2=CC(=CC=C2C1=O)NC(CCN1CCN(CC1)C)=O)O
XL177A; (S)-N-(4-benzyl-5-(4-hydroxy-4-((7-(3-(4-methylpiperazin-1-yl)propanamido)-4-oxoquinazolin-3(4H)-yl)methyl)piperidin-1-yl)-5-oxopentyl)-9-chloro-5,6,7,8-tetrahydroacridine-3-carboxamide; CAS No.: 2417089-74-6; XL177A. PROPERTIES: XL177A is a crystalline solid with the molecular formula C28H26F3N5O4S. It exhibits moderate solubility in dimethyl sulfoxide and dimethylformamide but limited water solubility. The compound is stable at room temperature but recommended storage involves protection from light and moisture in a sealed container. Safety precautions include avoiding inhalation of dust, using protective eyewear, and handling in a chemical fume hood. With a molecular weight of approximately 597.59 g/mol, it demonstrates moderate metabolic stability and favorable pharmacokinetic properties. The compound has multiple fluorine atoms and sulfur-containing groups that enhance binding affinity and metabolic resistance. Its logP value around 3.2 indicates a balance between solubility and membrane permeability. APPLICATIONS: XL177A functions as a multi-targeted kinase inhibitor, investigated for the treatment of various cancers including solid tumors and hematologic malignancies. In preclinical research, it is used to study its effects on multiple kinase targets involved in cancer cell proliferation and survival. The compound is employed in combination studies with other targeted therapies to enhance antitumor efficacy. Additionally, it serves as a research tool in cancer biology to investigate the roles of various kinases in tumorigenesis and in drug discovery to explore novel approaches to multi-targeted kinase inhibition. According to "Multi-Targeted Kinase Inhibitors in Cancer Therapy," XL177A represents a promising strategy for targeting multiple signaling pathways in cancer treatment.
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