Leptomycin B
$800.00
CAS No.: 87081-35-4
Catalog No.: WLZ1459
Purity: 95%
MF: C33H48O6
MW: 540.741
Storage: 2-8 degree Celsius
SMILES: C(O)(=O)/C=C(\C)/C[C@H](C)[C@@H](O)[C@H](C)C(=O)[C@H](C)/C=C(\C)/C=C/C[C@@H](C)/C=C(/CC)\C=C\[C@@H]1OC(=O)C=C[C@@H]1C
Catalog No.: WLZ1459
Purity: 95%
MF: C33H48O6
MW: 540.741
Storage: 2-8 degree Celsius
SMILES: C(O)(=O)/C=C(\C)/C[C@H](C)[C@@H](O)[C@H](C)C(=O)[C@H](C)/C=C(\C)/C=C/C[C@@H](C)/C=C(/CC)\C=C\[C@@H]1OC(=O)C=C[C@@H]1C
CAS No.: 87081-35-4; Leptomycin B. PROPERTIES: Leptomycin B is a cyclicdepsipeptide antibiotic with molecular formula C45H73NO13 and molar mass 883.1 g/mol. It appears as amorphous beige powder with high molecular complexity. The compound exhibits limited aqueous solubility (<0.1 mg/mL) but dissolves in methanol or DMSO. Recommended storage is at -20 C in glass vials under nitrogen atmosphere. Safety precautions emphasize using chemical-resistant gloves and working in certified fume hoods due to its potential cytotoxicity. APPLICATIONS: Leptomycin B is predominantly utilized as an inhibitor of CRM1-dependent nuclear export. In cancer research, it induces nuclear retention of tumor suppressor proteins, as described in Cancer Research mechanistic studies on p53 stabilization. For virology applications, the compound inhibits viral protein nuclear export, with Journal of Virology publications detailing its antiviral activity against HIV and influenza. In stem cell biology, Leptomycin B modulates nuclear localization of transcription factors to influence differentiation pathways, as reported in Cell Stem Cell developmental studies. Additionally, researchers employ this reagent in studying nuclear-cytoplasmic transport mechanisms, with Molecular Biology of the Cell articles outlining its role in identifying novel exportin substrates and regulatory pathways.
Reviews
Write Your Own Review