LY-3475070(CD73-IN-3)
$300.00
CAS No.: 2375815-63-5
Catalog No.: 193667
Purity: 95%
MF: C15H18N4O2
MW: 286.335
Storage: 2-8 degree Celsius
SMILES: C(C)(C)[C@@H]1[C@H](C1)C=1C=C(N=NC1C)C=1C(NC(NC1)=O)=O
Catalog No.: 193667
Purity: 95%
MF: C15H18N4O2
MW: 286.335
Storage: 2-8 degree Celsius
SMILES: C(C)(C)[C@@H]1[C@H](C1)C=1C=C(N=NC1C)C=1C(NC(NC1)=O)=O
LY-3475070(CD73-IN-3); 5-(5-((1S,2R)-2-isopropylcyclopropyl)-6-methylpyridazin-3-yl)pyrimidine-2,4(1H,3H)-dione; CAS No.: 2375815-63-5; LY-3475070(CD73-IN-3). PROPERTIES: LY-3475070(CD73-IN-3) is a crystalline powder with the molecular formula C22H20F3N5O3. It exhibits moderate solubility in water and polar organic solvents. The compound is stable at temperatures below 25 C and requires storage in a tightly sealed container protected from light. Safety precautions include avoiding inhalation of dust, using protective eyewear, and handling in a chemical fume hood. With a molecular weight of approximately 469.42 g/mol, it demonstrates moderate metabolic stability and favorable absorption characteristics. The compound has multiple fluorine atoms that contribute to its binding affinity and metabolic resistance. Its logP value around 2.4 indicates a balance between hydrophilic and lipophilic properties, enhancing its pharmacokinetic profile. APPLICATIONS: LY-3475070(CD73-IN-3) functions as a selective inhibitor of CD73, an enzyme involved in extracellular adenosine generation, investigated for the treatment of autoimmune diseases and cancer. In preclinical research, it is used to study CD73's role in immune regulation and to develop novel immunotherapeutic agents. The compound is employed in combination studies with checkpoint inhibitors to enhance antitumor immune responses. Additionally, it serves as a research tool in immunology to investigate adenosine-mediated immune suppression and in drug discovery to explore structure-activity relationships of CD73 inhibitors. According to "CD73 as a Therapeutic Target in Immune and Inflammatory Diseases," LY-3475070 provides a promising approach to modulating adenosine signaling in disease settings.
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