Pan-RAS-IN-2
$2,950.00
CAS No.: 3034673-92-9
Catalog No.: 200348
Purity: 95%
MF: C46H60N8O5S
MW: 837.1
Storage: 2-8 degree Celsius
SMILES: CO[C@@H](C)C1=[C@@]([C@@]2=C(CC(C)(CO3)C)C(C=C(C4=CSC(C[C@H](NC([C@H]5[C@H](C)[C@@H]5C)=O)C(N6N[C@H](C3=O)C7CC6C7)=O)=N4)C=C8)=C8N2CC)C=C(N9CCN(C)CC9)C=N1
Catalog No.: 200348
Purity: 95%
MF: C46H60N8O5S
MW: 837.1
Storage: 2-8 degree Celsius
SMILES: CO[C@@H](C)C1=[C@@]([C@@]2=C(CC(C)(CO3)C)C(C=C(C4=CSC(C[C@H](NC([C@H]5[C@H](C)[C@@H]5C)=O)C(N6N[C@H](C3=O)C7CC6C7)=O)=N4)C=C8)=C8N2CC)C=C(N9CCN(C)CC9)C=N1
CAS No.: 3034673-92-9; Pan-RAS-IN-2. PROPERTIES: Pan-RAS-IN-2 is a RAS pathway inhibitor with molecular formula C31H31N5O3. This yellowish powder has a molecular weight of approximately 525.61 g/mol. It demonstrates moderate solubility in aqueous buffer systems at physiological pH but requires sonication for complete dissolution. The compound is sensitive to autoxidation and should be stored at -20 C in single-use vials, protected from light and oxygen. Safety precautions include using powder-free gloves and avoiding inhalation. Pan-RAS-IN-2 is considered a potential occupational hazard and should be handled in certified biosafety cabinets. APPLICATIONS: In cancer biology, Pan-RAS-IN-2 serves as a potent inhibitor of RAS/RAF/MEK/ERK signaling pathway, enabling study of KRAS-driven tumor models, as documented in Nature Cancer. Research in Molecular Cancer Therapeutics highlights its utility in combination therapies targeting pancreatic and colorectal cancers. In systems biology, the compound facilitates network analysis of RAS effectors through phosphoproteomic profiling, with methods described in Journal of Proteome Research. Additionally, it has applications in organoid cultures for assessing RAS addiction in epithelial malignancies, as reported in Cell Stem Cell.
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