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Valdecoxib Impurity B; 4-(5-methyl-3-phenylisoxazol-4-yl)-N-((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)benzenesulfonamide; CAS No.: 1373038-60-8;Valdecoxib Impurity B. PROPERTIES: Valdecoxib Impurity B is a white to pale yellow crystalline solid with a molecular formula of C18H16F2N2O3S and a molecular weight of 390.40 g/mol. It has limited aqueous solubility but dissolves in common organic solvents. Proper storage requires keeping it at 4 C in a desiccator to prevent moisture absorption. When handling, chemical-resistant gloves and eye protection are recommended due to potential skin and eye irritation. APPLICATIONS: Valdecoxib Impurity B is a process-related impurity of the COX-2 inhibitor valdecoxib. In pharmaceutical quality control, it serves as a reference standard for impurity profiling and method validation in drug substance and product analysis (source: Journal of Pharmaceutical and Biomedical Analysis). The compound helps in understanding degradation pathways and stability characteristics of valdecoxib formulations. Additionally, it provides insights into synthetic process optimization by identifying potential impurities arising from manufacturing steps (source: Organic Process Research & Development).