Sabizabulin
$400.00
CAS No.: 1332881-26-1
Catalog No.: 193368
Purity: 95%
MF: C21H19N3O4
MW: 377.4
Storage: 2-8 degree Celsius
SMILES: N1C=C(C2=CC=CC=C12)C=1NC(=CN1)C(=O)C1=CC(=C(C(=C1)OC)OC)OC
Catalog No.: 193368
Purity: 95%
MF: C21H19N3O4
MW: 377.4
Storage: 2-8 degree Celsius
SMILES: N1C=C(C2=CC=CC=C12)C=1NC(=CN1)C(=O)C1=CC(=C(C(=C1)OC)OC)OC
Sabizabulin; (2-(1H-indol-3-yl)-1H-imidazol-5-yl)(3,4,5-trimethoxyphenyl)methanone; CAS No.: 1332881-26-1; Sabizabulin. PROPERTIES: Sabizabulin is a white crystalline powder with the molecular formula C34H34N8O6. It demonstrates moderate solubility in dimethyl sulfoxide and dimethylformamide but limited water solubility. The compound is stable at temperatures below 25 C and requires storage in a tightly sealed container protected from light. Safety precautions include wearing protective clothing, avoiding inhalation of dust, and using a fume hood during handling. With a molecular weight of approximately 686.72 g/mol, it exhibits complex pharmacokinetic behavior characterized by moderate plasma protein binding and nonlinear metabolism. The compound has multiple chiral centers, contributing to its stereochemical complexity and potential for enantioselective effects. Its logP value around 2.1 indicates a balance between hydrophilic and lipophilic properties. APPLICATIONS: Sabizabulin is a microtubule-targeting agent under investigation for anticancer therapy, particularly in non-small cell lung cancer and other solid tumors. In clinical trials, it has shown activity as a single agent and in combination regimens. The compound is employed in oncology research to study tubulin dynamics and in mechanistic studies of drug-resistant cancer cells. Additionally, it is used in pharmacokinetic studies to evaluate drug-drug interactions and in formulation development for improved bioavailability. According to clinical trial reports published in "The Lancet Oncology," Sabizabulin demonstrates promising antitumor activity and represents a novel approach to microtubule inhibition in cancer treatment.
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