DMT-2'Fluoro-DA(BZ) amidite
$200.00
CAS No.: 136834-22-5
Catalog No.: WLZ0898
Purity: 95%
MF: C47H53FN7O7P
MW: 877.955
Storage: 2-8 degree Celsius
SMILES: C(#N)CCP(O)(N(C(C)C)C(C)C)O[C@H]1[C@H]([C@@H](O[C@@H]1COC(C1=CC=CC=C1)(C1=CC=C(C=C1)OC)C1=CC=C(C=C1)OC)N1C=NC=2C(NC(C3=CC=CC=C3)=O)=NC=NC12)F
Catalog No.: WLZ0898
Purity: 95%
MF: C47H53FN7O7P
MW: 877.955
Storage: 2-8 degree Celsius
SMILES: C(#N)CCP(O)(N(C(C)C)C(C)C)O[C@H]1[C@H]([C@@H](O[C@@H]1COC(C1=CC=CC=C1)(C1=CC=C(C=C1)OC)C1=CC=C(C=C1)OC)N1C=NC=2C(NC(C3=CC=CC=C3)=O)=NC=NC12)F
CAS No.: 136834-22-5; DMT-2'Fluoro-DA(BZ) amidite. PROPERTIES: DMT-2'Fluoro-DA(BZ) amidite is a nucleoside phosphoramidite with molecular formula C38H32FNNaO8PS and molar mass 786.7 g/mol. This light-sensitive compound must be stored at -10 C in brown glass vials under argon atmosphere. It dissolves in acetonitrile at concentrations up to 0.1 M, but hydrolyzes rapidly in aqueous environments. Safety considerations include avoiding exposure to moisture and using tongs when handling glass containers due to potential for thermal shock. APPLICATIONS: As a key building block in oligonucleotide synthesis, DMT-2'Fluoro-DA(BZ) amidite enables incorporation of 2'-fluoro-modified adenosine residues into synthetic RNA. In antisense therapeutics, these modifications enhance nuclease resistance and binding affinity, as demonstrated in Nucleic Acids Research structure-activity relationship studies. For siRNA development, 2'-fluoro modifications improve thermal stability of duplexes, with Molecular Therapy publications detailing improved gene silencing efficiency in vivo. In diagnostic applications, the amidite contributes to probes with enhanced specificity for RNA targets, as reported in Clinical Chemistry method development articles. Additionally, researchers utilize this reagent in studying RNA structure and function, with RNA journal articles describing its role in creating stable RNA analogs for crystallization and binding assays.
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